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We have a 12 year old cat who was diagnosed with CRF (chronic renal failure) and need to give her subcutaneous Ringers Lactate 150 cc twice weekly.
I have done this for a couple of my cats. Both were pretty easy going and I think that was a big part of my success. One just jumped on my lap and thought it was just part of the fun. I can't imagine how well I would do if the cat struggled, or was really distressed by it.
According to this article, it is easier if two people do it, you pinch some loose skin and you give the injection while the cat is eating. vcahospitals.com/